Which factor deficiency is considered the only autosomal recessive hemophilia?

Which factor deficiency is considered the only autosomal recessive hemophilia?

• A. Hemophilia A
• B. Hemophilia C
• C. Hemophilia B
• D. Factor XI deficiency

Answer: (B)

Hemophilia C is characterized as an autosomal recessive disorder, which distinguishes it from other types of hemophilia that are linked to X-chromosome mutations. Hemophilia A and Hemophilia B are both X-linked conditions, meaning they primarily affect males and are inherited through the X chromosome from carrier mothers. In individuals with Hemophilia A, there is a deficiency in Factor VIII, while Hemophilia B involves a deficiency of Factor IX. Factor XI deficiency, while it presents a bleeding disorder similar to hemophilia, is also not classified strictly as hemophilia and is typically inherited in an autosomal manner, but it does not have the same phenotypic severity that is observed in Hemophilia A or B. In contrast, Hemophilia C, caused by a deficiency in Factor XI, occurs equally in both genders and can be passed down regardless of the sex of the parent. The autosomal recessive inheritance requires both copies of the gene to be defective for the disorder to manifest, which aligns with the expected inheritance pattern of Hemophilia C. As a result, Hemophilia C is the only form of hemophilia classified under autosomal recessive transmission, making it the correct response.

Hemophilia C is characterized as an autosomal recessive disorder, which distinguishes it from other types of hemophilia that are linked to X-chromosome mutations. Hemophilia A and Hemophilia B are both X-linked conditions, meaning they primarily affect males and are inherited through the X chromosome from carrier mothers. In individuals with Hemophilia A, there is a deficiency in Factor VIII, while Hemophilia B involves a deficiency of Factor IX.

Factor XI deficiency, while it presents a bleeding disorder similar to hemophilia, is also not classified strictly as hemophilia and is typically inherited in an autosomal manner, but it does not have the same phenotypic severity that is observed in Hemophilia A or B.

In contrast, Hemophilia C, caused by a deficiency in Factor XI, occurs equally in both genders and can be passed down regardless of the sex of the parent. The autosomal recessive inheritance requires both copies of the gene to be defective for the disorder to manifest, which aligns with the expected inheritance pattern of Hemophilia C. As a result, Hemophilia C is the only form of hemophilia classified under autosomal recessive transmission, making it the correct response.