Which congenital condition is associated with duodenal atresia in a newborn?

Which congenital condition is associated with duodenal atresia in a newborn?

• A. Turner syndrome
• B. Trisomy 21
• C. Marfan syndrome
• D. Edward syndrome

Answer: (B)

Duodenal atresia, which is a congenital condition characterized by a blockage in the duodenum, is strongly associated with Trisomy 21, also known as Down syndrome. This condition occurs due to an abnormal division of chromosome 21, leading to various physical and intellectual disabilities. In infants with Trisomy 21, there is an increased incidence of gastrointestinal anomalies, including duodenal atresia, which is present in approximately 20% of these cases. The malformation arises during early fetal development, affecting the normal formation of the duodenum. Other congenital syndromes listed, such as Turner syndrome, Marfan syndrome, and Edward syndrome, do not have a significant association with duodenal atresia. For instance, Turner syndrome primarily affects females and is associated with cardiovascular defects and growth issues, but not typically with gastrointestinal tract obstructions. Similarly, Marfan syndrome, a connective tissue disorder, has its own set of distinct features such as cardiovascular and skeletal abnormalities, while Edward syndrome, associated with multiple congenital defects, is not typically linked to duodenal atresia specifically. Thus, the connection between duodenal atresia and Trisomy 21 is well-established in medical literature, unders

Duodenal atresia, which is a congenital condition characterized by a blockage in the duodenum, is strongly associated with Trisomy 21, also known as Down syndrome. This condition occurs due to an abnormal division of chromosome 21, leading to various physical and intellectual disabilities. In infants with Trisomy 21, there is an increased incidence of gastrointestinal anomalies, including duodenal atresia, which is present in approximately 20% of these cases. The malformation arises during early fetal development, affecting the normal formation of the duodenum.

Other congenital syndromes listed, such as Turner syndrome, Marfan syndrome, and Edward syndrome, do not have a significant association with duodenal atresia. For instance, Turner syndrome primarily affects females and is associated with cardiovascular defects and growth issues, but not typically with gastrointestinal tract obstructions. Similarly, Marfan syndrome, a connective tissue disorder, has its own set of distinct features such as cardiovascular and skeletal abnormalities, while Edward syndrome, associated with multiple congenital defects, is not typically linked to duodenal atresia specifically.

Thus, the connection between duodenal atresia and Trisomy 21 is well-established in medical literature, unders